AHA News: Women and Men Tolerate Heart Transplants Equally Well, But Men May Get Better Hearts

FRIDAY, Oct. 11, 2019 (American Heart Association News) — Women are just as likely as men to survive after a heart transplant despite often getting poorer-quality donor hearts, new research shows.

The findings, published this week in the American Heart Association journal Circulation: Heart Failure, sought to shed new light on what role, if any, gender plays in surviving a heart transplant. Past research on post-transplant survival rates and gender have told conflicting stories.

For the new study, researchers looked at data from 34,198 international heart transplant recipients from 2004 to 2014 and, after adjusting for recipient and donor factors, they found “no significant survival difference” between men and women.

“That’s a pretty novel finding,” said study author Dr. Yasbanoo Moayedi, a postdoctoral medical fellow at Stanford University in California. “We already know that women are hugely under-represented as recipients of heart transplants, but the striking thing about the new findings is there’s no difference in survival when matched to their male counterparts.”

The study also found women who get heart transplants appear to have lower-risk features than male recipients, with fewer instances of diabetes, high blood pressure, smoking, peripheral vascular disease and past cardiovascular surgery. Yet, women appear to receive higher-risk hearts than men.

“We need to better understand the matching of risk with recipient,” Moayedi said. “We hypothesize that women tend to deteriorate more acutely, and they’re sicker, so they take any heart that’s available.”

She said the findings suggest women with advanced heart failure need to be referred a bit earlier for transplant.

“One takeaway of the study is that maybe we’re missing the optimal window [for women],” she said. “Many factors may determine access to transplant, but gender should not be one of the them.”

The study was limited by its observational nature and its lack of data on waitlist mortalities, donor race and information about how sick patients where when they received a transplant.

Dr. Monica Colvin, a heart failure-transplant cardiologist who was not involved in the research, called it “a contemporary analysis” because it included newer devices and current medical therapy.

“There have been anecdotes of women having worse survival than men after heart transplant and studies have been conflicting,” said Colvin, director of the Heart Failure Network Strategy at the University of Michigan. “This study should dispel that myth and inform doctors that there really is no difference. We should not delay or defer referral for this lifesaving treatment based on concern for differential survival in women.”

An estimated 6.2 million U.S. adults have heart failure. In 2018, there were 3,408 heart transplants, according to the federal Organ Procurement and Transplantation Network.

Moayedi would like to see future studies explore why more women don’t undergo heart transplants and how a doctor’s gender might play into that decision.

“Is it that women don’t see themselves worthy enough for a heart transplant? As a patient, should I be more of an advocate for my symptoms? These things need to be looked at more systematically to learn how to best help the patient,” Moayedi said.

Colvin advises women with advanced heart failure to be seen at an advanced heart failure center “and seek out as much information as they can. It’s important to know what all your options are.”

© 2019 HealthDay. All rights reserved.

Posted: October 2019

Drugs.com – Daily MedNews

State Department’s Top Drug Warrior, William Brownfield, Says Federal Government Must Tolerate Making Marijuana Legal

According to Reason, William Brownfield, the assistant secretary of state for international narcotics and law enforcement affairs, called for flexibility in interpreting anti-drug treaties.

“How could I, a representative of the government of the United States of America, be intolerant of a government that permits any experimentation with legalization of marijuana if two of the 50 states of the United States of America have chosen to walk down that road?”

When asked about the federal government’s position on the regulation and taxation of marijuana in Colorado and Washington, Brownfield described a clearly prescribed policy:

William Brownfield

“The deputy attorney general’s words were that the federal government will not intervene in the application of the laws of Washington and Colorado on marijuana legalization, but will monitor and hold them responsible for performance in eight specifically designated areas…. We have a national interest to ensure that this does not cause undue harm….”

“The United States of America reserves the right and can at any time it chooses enforce the law against marijuana and cannabis cultivation, production, sale, purchase, and consumption in Washington state and Colorado. The deputy attorney general in a public document has asserted that for now we will not do that unless it crosses the line in eight specifically identified categories in those two states.”

Although there is a long way for the federal government to go in terms of completely eliminating its prohibitionist attitude, those associated have been compelled by the political circumstances in the U.S. to accept that there is value to alternative policies. This is a good sign for countries that have been pressured by the U.S. to mimic and help enforce American prohibition.


MPP Blog

Judge will not Tolerate Abusive Cop

This film is in The Public Interest. Please visit my channel www.youtube.com The people at StoptheDrugWar.com posted this news report regarding a police officer who arrested man who was believed, by the officer to have marijuana. The cop couldn’t find the marijuana so he then assumed the man was swallowing it. To prevent this the officer then began chocking the man, who was restrained in handcuffs and who didn’t try to fight or resist in any way. It is bad news when cops think they have the right to choke restrained individuals period. And any cop who so thinks should be removed from duty permanently. A local judge in Mount Juliet, TN, where the cop assaulted the man, was so dismayed by the unprovoked attack he threw the officer out of his court and told him he would dismiss any case he files. I don’t blame the judge. This office is unreliable. I’ll go further, this officer is a criminal. The problems got worse for the officer. Office Crosby, the uniformed thug in question, was attempting to force the man to spit out marijuana. The man’s refusal to do so meant more choking of him in order to force him to produce the evidence. The stupid officer never considered another alternative — that the man had no marijuana and couldn’t spit it out since it wasn’t there. In fact, tests on the man proved that to be the case. NO marijuana was in his system at all. None that day, none in the past that they could find. Remember a little incident in history called the Holy Inquisition. A
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Health Canada marks up medical marijuana 1,500%.(City): An article from: Winnipeg Free Press

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Title: Health Canada marks up medical marijuana 1,500%.(City)
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