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Some May Be Vulnerable to Severe Skin Reaction While Using Gout Drug

TUESDAY, Oct. 1, 2019 — Some gout patients with heart or kidney disease might be more susceptible to severe skin reactions while taking the gout medication allopurinol, researchers report.

“Our findings suggest that heart disease, like chronic kidney disease, is a risk factor for allopurinol-associated severe cutaneous adverse reactions that warrants adoption of precautionary measures against these reactions,” said researcher Dr. Hyon Choi, from the Department of Rheumatology, Allergy and Immunology at Massachusetts General Hospital in Boston.

Gout is form of inflammatory arthritis that develops in people who have high levels of uric acid in their blood. The acid can form needle-like crystals in joints and cause sudden, severe episodes of pain, tenderness, redness, warmth and swelling.

An earlier study found a link between heart disease and an increased risk of hospitalization for people who had a severe skin reaction to allopurinol.

For the latest study, Canadian and U.S. researchers used data from nearly 5 million people in British Columbia. More than 130,000 of these people were on allopurinol. Of these patients, those with heart disease and chronic kidney disease had a higher risk of severe skin reactions than those without such conditions.

People with the genetic marker HLA-B*5801, which is more common in Asian and black people, have a significantly higher risk of this adverse reaction than people without the mutation.

The report was published Sept. 30 in the CMAJ.

The U.S. Food and Drug Administration recently warned patients about the risk of cardiovascular events from the gout medication febuxostat, so the number of prescriptions for allopurinol will probably increase, the researchers noted.

But severe skin reactions are rare, and allopurinol plays an important role in managing gout, they added.

“Physicians who prescribe allopurinol should look for these risk factors so that they may consider initiating lower-dosage allopurinol and other precautions, which may prevent this rare but serious adverse reaction,” Choi and his co-authors concluded in a journal news release.

More information

For more on gout, see the Arthritis Foundation.

© 2019 HealthDay. All rights reserved.

Posted: October 2019

Drugs.com – Daily MedNews

How Athletes Can Benefit From Using CBD?

With cannabis being legalized in many states and the increasing use of marijuana for medicinal purposes, more studies are being conducted on the benefits of marijuana.

There is certainly a lot of talk about CBD in the sports world and some contradicting opinions as well. It’s not a secret that many athletes use cannabis to boost their training or to help alleviate pain. In this article, we will shed some light on the matter and talk about ways CBD can help athletes.

Health Benefits of CBD

When speaking about the health benefits of marijuana, we mostly refer to CBD. CBD is one of the dominant components in the marijuana plant that has gained a lot of attention recently. It’s the non-psychoactive component that does not make you high but does provide a feeling of relaxation. In recent years, numerous health benefits of CBD have been discovered. While research is limited, it is safe to assert that CBD can successfully be applied to help with various medical conditions.

It has been used for helping cancer patients for years as CBD is known for its ability to reduce nausea and increase food appetite. This cannabinoid is also known to be good for chronic pain management, anxiety, depression, and many other medical conditions including Parkinson’s disease.

CBD and Pain Management

A study conducted on the effects of cannabis on athletes’ health and performance (published in 2018) showed promising results. While the results did not show that using cannabis can enhance athletes’ performance, the use of the substance for pain management proved to be undeniable.

Due to its ability to relieve pain, cannabis is a more natural alternative to prescription medications such as ibuprofen or aspirin. Using cannabis for pain management certainly has fewer negative effects when compared to pharmaceutical solutions. Many athletes use cannabis to alleviate pain and speed up their recovery after an injury.

Cannabis is known for its anti-inflammatory properties which means it can speed up the recovery of muscles. Although limited, the data gathered on the matter is reliable and showed that CBD is can help with medical conditions caused by inflammation including arthritis and liver injury.

Cannabis and Training

There are beliefs that CBD helps enhance athletes’ performance. However, there is no concrete evidence to support that claim. But it doesn’t harm or reduce their performance either. What we do know is that cannabis and training go hand in hand.

Cannabis helps relax and focus on training. It is also very effective post-training as it helps relax the muscles and recover from an intense workout session. Sore muscles, inflamed ligaments, and spasms are not an unusual occurrence after training and using cannabis can help reduce the effects.

Esquire magazine published an article in 2017 in which a professional trainer Scioli explained how cannabis aids performance. Scioli examined numerous different strains and believes the key is to find the one that is right for you instead of simply buying any weed you can find. If the motivation for training is the problem, Scioli says that Cannabis Sativa is the right choice. It boosts motivation and gives you energy.

Indica strains have a more therapeutic effect so it is a better choice if you want to relax prior to your workout. When coaching his clients, Scioli claims that cannabis extracts are far more effective than pharmaceutical stimulants.

Intense workout sessions can leave athletes tired and feeling unable to perform the following day. That is why athletes of high-risk sports use cannabis to relieve soreness and stiffness after a workout and to stay in a great condition the following day. Scioli also pointed out that using cannabis can help gain muscle mass as the substance stimulates the appetite.

CBD and Stress Relief

Athletes are under a lot of stress, both physically and mentally. They are must show excellent performance, endure tough workout sessions, and stay in their best shape. One injury can end their careers and so the pressure is huge. To help them endure all that, the majority of athletes become addicted to pain medications which have numerous harmful effects.  

That is another reason why CBD and sports go hand in hand. Cannabis can help athletes to relieve stress and relax and it is estimated that about half of athletes use CBD products to help them. Such pressure can increase anxiety and depression among athletes and CBD has a proven positive effect on both.

Despite the controversy surrounding cannabis, there is no doubt that many athletes use and will continue to use cannabis to help them alleviate pain and relieve stress. However, the problem is that cannabis is still illegal in many states and athletes are tested on a regular basis.

Still, the fact that they choose to use an illegal substance for pain relief instead of harmful prescribed medications does speak for itself. However, more research is necessary to determine how athletes can benefit from CBD.

Shane Dwyer
Author: Shane Dwyer
Shane Dwyer is a cannabis advocate who isn’t afraid to tell the world about it! You can find his views, rants, and tips published regularly at The 420 Times.

Marijuana & Cannabis News – The 420 Times

Guide for using Medical Cannabis

How to use medical cannabis? Cannabis or marijuana has long been considered an effective way to cure different complications. It has a turbulent history in Canada and the United States, and since its legalization in these developed countries, more and more people have increased their dependence on marijuana and other similar products, as they consider it a good way to cure cancer, AIDS, and depression.

Facts about Marijuana

The first fact about marijuana is that it is being used and bought every day by over 60 percent of Americans. You must be one of them; medical marijuana comes from pure indica plant that is grown only in particular parts of the world. If you are in the United States or another developed country, then it will be easy for you to buy marijuana or grow its plant at home. You would be amazed to know that it is easy to be grown in Canada as the environment in this country is quite feasible.

The Case for Medical Cannabis

When some health experts understood the benefits of medical marijuana, they brought this matter to the world’s attention that this product should not be banned from any part of the world. This opened a case for medical cannabis, and with time, more and more people began growing it at home, in farmhouses and other empty places. After its legalization.

How to Obtain Medical Cannabis

With over 100 chemicals, known as cannabinoids in cannabis, there are two major chemicals found in marijuana that are used to treat different illnesses. These are named as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). How to use medical cannabis? You can get best out of the cannabis only if you develop an understanding of how these chemicals are used to cure different diseases  and what are their short term and long term effects. Fortunately, CBD and THC are being used in different Chinese, American and other medicines, as well as in food, as these are said to be giving good results.

Dosing Medical Cannabis

How marijuana helps? This could be of help only when you know how much doses are needed. Ideally, you can go to the doctor to get information on it, but the best way is to use a handful of marijuana to cure cancer, HIV/AIDS and other similar complications.

Choosing a Delivery Method

The delivery method of medical marijuana depends on your physical or mental condition as well as on what the doctor prescribes. For example, they might want you to use it in the form of the vaporizer, or you might be asked to smoke the weed. It is mandatory to select the right kind of method so that you can get good results within days or weeks.

Talking with Your Doctor

As we already said, you should speak to your healthcare expert regarding how much marijuana is needed to cure a specific illness and what is the best time to use it. There is no need to consult a neighbor or an elder, as the prescription or suggestion of a doctor would be the best option.

Shane Dwyer
Author: Shane Dwyer
Shane Dwyer is a cannabis advocate who isn’t afraid to tell the world about it! You can find his views, rants, and tips published regularly at The 420 Times.

Marijuana & Cannabis News – The 420 Times

How to De-stress Yourself Using High-Grade CBD Oil

While stress happens to be a normal and healthy reaction to how the body reacts or adjusts to changes, it may lead to adverse health issues such as depression, if a person continuously faces these changes without taking a break. Other health issues that induce stress include:

  1. Anxiety
  2. Digestive issues
  3. Pain of any kind
  4. Sleep disorders such as insomnia
  5. Auto-immune diseases
  6. Conditions of the skin like eczema
  7. Heart disease
  8. Problems with weight
  9. Problems with the reproductive system
  10. Problems with memory

Stress signs can affect a person’s emotional state, physical state, cognitive state, and behavioral state. There are several natural ways to relieve stress, but in this article, we’ll handle stress the cannabidiol (CBD) way. 

Below are some of the best ways you can de-stress using CBD oil:

1.  Full Spectrum CBD Capsules

CBD can be taken in several forms, including capsules. These capsules are quite easy to use as you don’t need to mix them with anything. You simply just swallow. They are also quite easy to carry around. They:

  • are free from pesticide.
  • contain hemp CBD oil that’s non-GMO.
  • are extracted from the stalks and stems of the mature hemp plant. 
  • contain high-quality fractionated MCT coconut oil (MCT: Medium Chain Triglyceride) and extracted hemp oil

2.  CBD Gummies

Instead of the common pills, there’s a whole new way for you to enjoy your CBD. If you’re just starting out, these gummies are the perfect pick. They deliver the perfect dose of hemp designed to help de-stress, and they come in different shapes and flavors. Finding the best CBD gummies may turn out to be quite a challenge. However, with knowledge about different brands and sources where you can find your chewable, you’re good to go. The site below can be quite helpful:

https://www.zachattacksupplements.com/products/cbd-oil/

3.  Jack Herer Terpsolate

If you hate the taste hemp leaves in your mouth, this Terpsolate CBD is for you. It has a delightful taste and gives complete relief from stress. The product also has a very pleasing and inviting scent. The only ingredients it has include anhydrous hemp oil, terpenoids, and hemp-derived CBD isolates.

4.  CBD Oil Vape Pen

You can now have your medicine in a vape – quite a luxury, right? This luxurious oil vape pen has been carefully formulated to relieve stress using high-quality CBD. It comes in different flavors and aromas. The product is also 100% natural and organic – no pesticides, no GMO hemp-derived CBD, and all flavorings added are all natural.

5.  CBD Tincture Oil Drops

The one thing we love about CBD oil drops is that it’s tetrahydrocannabinol (THC)-free. The product is formulated with 99% pure CBD isolate. It’s pesticide-free, squeezed from stalks and stems of the mature hemp plant, and is also formulated with non-GMO industrial hemp. This CBD oil drop contains coconut oil and anhydrous hemp oil as its carrier oil. It’s quite easy to use. You can simply just add it to your food or drinks, or you can as well ingest it by placing the recommended drops under your tongue.

Shane Dwyer
Author: Shane Dwyer
Shane Dwyer is a cannabis advocate who isn’t afraid to tell the world about it! You can find his views, rants, and tips published regularly at The 420 Times.

Marijuana & Cannabis News – The 420 Times

Lamar Odom Admits to Using Prosthetic Penis to Pass Olympic Drug Test

Lamar Odom has had one heck of a life, and it’s all being documented in his new book, Darkness to Light, a memoir where he comes clean about many topics that made the media rounds in his storied career on and off of the basketball courts.  In one section, he admits to using a prosthetic penis to pass a drug test in advance of making the United States Olympic team.

Lamar Odom Beats Drug Test to Play for Team USA in the Greece Olympics

Should this surprise you?  It definitely doesn’t surprise me, as drug tests have always been something that people of all walks of life have been able to get around for many decades.  In fact, I’ve dedicated an entire portion of this site to educating people about devices and products used to pass marijuana drug tests, and due to the popularity of the content, I’ve expanded on that over time to include other types of drug testing such as how to use fake urine to pass a piss test, as well as how you can even beat a hair follicle drug test.  Look, if there is something worth gaining by passing a test, people will go to large measure to try to beat them.

Lamar Odom said it was a dream to play for Team USA, and he mentioned that he smoked weed “every day” that summer leading up to the Olympics, so he had to pass a test and was worried about it.  In specific, he detailed how he used a prosthetic penis and used his trainers pee to pass the test.  When the supervisor checked the temperature of the urine sample and was satisfied with it, he said “welcome to team USA.”

And that was it.  Odom made the team and was on his way to playing in the Olympics with LeBron James, Dwayne Wade, and others.

I recently wrote about companies and why they are backing off on drug testing (which is a great read and shows you how many people smoke and how it limits the talent pool if people are going to continue to drug test) but in situations like the Olympic Games, we’ll never see any backing off on testing for drugs, doping, and anything else to keep a level playing field.

I’ve been smoking for as long as I can remember, and I’ve done a lot of homework on passing drug tests.  If you really need to pass a test, for any type of situation, the place to visit is Test Clear.  Read my review and you’ll see their entire line of products that can help you pass any test.  I even have a 10% off coupon code which you can use on any product of your choice.

While I only read the story on Fox News about Lamar Odom, I think I’m going to have to get his book.  Any man who has married a Kardashian, cheated on her like heck and lived to tell about it, and almost died in a brothel in Nevada is a guy I want to learn more about.  Viva Lamar!

Shane Dwyer
Author: Shane Dwyer
Shane Dwyer is a cannabis advocate who isn’t afraid to tell the world about it! You can find his views, rants, and tips published regularly at The 420 Times.

Marijuana & Cannabis News – The 420 Times

An Antibiotic Alternative? Using a Virus to Fight Bacteria

WEDNESDAY, May 8, 2019 — Viruses and bacteria are the culprits behind the infectious diseases that plague humans. Researchers recently turned one against the other, using viruses to wipe out a potentially life-threatening bacterium in a 15-year-old girl with cystic fibrosis.

This old-time approach to battling bacterial infections might be worth another look in these days of antibiotic-resistant bacteria, a new paper argues.

Genetically engineered bacteriophages — viruses that infect and kill bacteria — successfully cleared up a severe antibiotic-resistant bacterial infection in the critically ill teenager, researchers said in a new study.

“This is the first use of ‘phages’ to treat this kind of infection with this kind of bacterium, and it’s the first time that anyone’s used ‘phages’ that have been genetically engineered to be more effective,” said study co-author Graham Hatfull. He’s a professor of biotechnology at the University of Pittsburgh.

The idea of using bacteriophages to battle human disease has been around for about a century. But it fell out of favor in the 1940s with the discovery of penicillin and other antibiotics, according to the BioTherapeutics Education & Research Foundation.

The notion of bacteriophage therapy is getting a second look now that some dangerous bacteria are developing resistance to widely used antibiotics.

In this case, a cocktail of three phages wiped out an infection of Mycobacterium abscessus that had plagued the young girl for eight years, then flared up after she underwent a double lung transplant as a result of cystic fibrosis.

“Mycobacterium abscessus — a bacterium that is one of the most daunting to treat — is in desperate need of effective therapies,” said Dr. Amesh Adalja, a senior scholar at the Johns Hopkins Center for Health Security in Baltimore.

“That this patient had a very positive response to intravenous phage therapies is an important milestone and hopefully will lead to more use of phages for this specific infection and for others,” said Adalja, who was not involved in the study.

“The antibiotic pipeline is rapidly running dry and the use of bacteriophages is increasingly proving to be one important solution to the looming infectious disease crisis the world faces,” he added.

The lung transplant occurred without any immediate problems, but afterward the patient was put on immunosuppressive drugs to help the body adapt to the new lungs, researchers said.

That gave the long-standing bacterial infection a chance to become widespread, despite treatment with multiple intravenous antibiotics.

The girl’s surgical wound site became infected, the liver became inflamed, and sores erupted on more than 20 locations on her legs, arms and buttocks, researchers said.

“The patient was not responding to antibiotics,” Hatfull said. “Our expertise is in the study of the bacteriophages, so we sought to try to find phages in our collection which would infect and kill this particular bacterial strain.”

Researchers wound up identifying three different phages that might effectively kill off the bacteria. They genetically improved the viruses to make them better able to tackle the infection.

They administered the phages intravenously and topically to the infected skin lesions. Within six months, the surgical wound and skin lesions healed, with no adverse effects, researchers said.

Bacteriophage therapy holds huge promise because it only attacks the specific bacteria it considers the enemy, Hatfull said.

“That specificity is in marked contrast to antibiotics, which often just blast away any of the bacteria in your body,” Hatfull said.

But that specificity is a drawback as well.

“They’re often so specific that even though they may infect and be useful for the strain that infects one patient, they may not attack very similar bacteria that infect other patients,” Hatfull said. “That’s really the conundrum with the use of the phages more broadly.”

Genetic research into phages and how they choose their targets could help open up bacteriophage therapy as an alternative to antibiotics, Hatfull said.

“If we could understand that at a basic research level, perhaps then we would be able to extend what appears to be a good outcome for one patient into a treatment that would be more broadly useful for more patients,” Hatfull said.

The study results appear online May 8 in the journal Nature Medicine.

More information

The BioTherapeutics Education & Research Foundation has more about bacteriophage therapy.

© 2019 HealthDay. All rights reserved.

Posted: May 2019

Drugs.com – Daily MedNews

The Very Real Risk of Using Baby Walkers

By Erin O’Donnell

baby in walker

It seems like a fun idea: Sitting your infant in a baby walker to give him a new way to scoot around your home. But a recent study found that an estimated 2,000 babies visit emergency rooms each year with walker-related injuries — often to the head and neck — after toppling down stairs.

Even when they’re on level ground, walkers allow babies to reach hot stoves, steaming mugs of coffee, appliance cords, and poisons, or to fall into pools before they fully understand these dangers, says Gary A. Smith, MD, DrPH, director of the Center for Injury Research and Policy at Nationwide Children’s Hospital in Columbus, OH, who led the study on walker injuries.

“The device is inherently dangerous by design, and for that reason simply shouldn’t be on the market,” he says. The American Academy of Pediatrics has called for a ban on the manufacture and sale of baby walkers, which are still sold in the U.S.

Smith’s research does reveal some good news: The number of walker-related injuries has declined dramatically since 1990, when more than 20,000 children visited emergency rooms due to walkers. In the following decade, companies began making stationary activity centers without wheels. And voluntary federal standards established in 1997 by the Consumer Product Safety Commission (CPSC) led companies to make wheeled walkers wider than typical doorways, or to manufacture them with a brake that halts the wheels if they drop over the edge of a step. The CPSC added stricter standards in 2010, preventing companies from importing walkers without those safety features.

Although these rules reduced the number of injuries, babies are still getting hurt. “The thing that gets my attention is that there’s a very high proportion of really severe injuries,” Smith says. These include skull fractures, concussions, and burns to the head and neck. Strong babies can override the brake to push themselves down stairs, and walkers zip around at lightning speed. “A child can move up to 4 feet a second in a mobile baby walker,” says Smith.

Smith acknowledges that well-meaning parents use walkers because they want to keep their infants stimulated and entertained. They believe babies will be safe if they just watch them closely. (They might also think that walkers will help babies learn to walk, which is untrue, he adds.) But Smith says he has met attentive, conscientious parents who were stunned by their child’s walker accident. “It doesn’t matter if you’re standing right there,” he says. “Kids are going to move so quickly that you don’t have time to react before they’re down the stairs.”

Continued

4 Tips

Parents may be tempted to buy baby walkers “to keep their children challenged, happy, and engaged,” says Smith. Here are better ways to keep your little one occupied and injury-free.

Tummy time: Smith is a fan of placing your infant on her belly on the floor for short periods. This gives her practice lifting her head, rolling over, pushing up on her hands and knees, and even starting to crawl.

Stationary activity centers: These toys are usually shaped like traditional baby walkers but lack wheels and keep your infant in one spot. The seats often swivel or allow Baby to bounce around.

Playpens: To keep Baby contained for a little while, consider a playpen (sometimes called a “play yard”). Never leave your baby in a mesh-sided playpen with the side lowered, though. And if the playpen has a raised changing table insert, remove it before putting Baby in to play.

High chairs: Need to keep Baby busy while you make dinner? The American Academy of Pediatrics suggests strapping older babies into a high chair to play with toys placed on the tray.

Find more articles, browse back issues, and read the current issue of WebMD Magazine.

Sources

SOURCES:

Gary A. Smith, MD, DrPH, director of the Center for Injury Research and Policy, Nationwide Children’s Hospital, Columbus, OH.

American Academy of Pediatrics: “Study: Infant walker injuries support AAP’s call for a ban.”

Pediatrics: “Infant Walker-Related Injuries in the United States.”

© 2019 WebMD, LLC. All rights reserved.

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WebMD Health

Israeli Team Announces First 3D-Printed Heart Using Human Cells

By Robert Preidt

HealthDay Reporter

MONDAY, April 15, 2019 (HealthDay News) — The world’s first complete 3D printer-generated heart, made using the patient’s own cells and materials, has been created in a lab.

Until now, success has been limited to printing only simple tissues without blood vessels.

“This is the first time anyone anywhere has successfully engineered and printed an entire heart replete with cells, blood vessels, ventricles and chambers,” said team leader Tal Dvir.

The printer-generated heart is only about a third the size of an actual human heart — and it doesn’t actually work. But it’s a groundbreaking step toward engineering customized organs that can be transplanted with less risk of rejection.

“This heart is made from human cells and patient-specific biological materials,” said Dvir, a researcher at the Sagol Center for Regenerative Biotechnology at Tel Aviv University in Israel. “In our process these materials serve as the bio-inks, substances made of sugars and proteins that can be used for 3D printing of complex tissue models.”

Dvir noted that scientists have managed to print a 3D structure of a heart before, but not with cells or blood vessels. “Our results demonstrate the potential of our approach for engineering personalized tissue and organ replacement in the future,” he said in a university news release.

The research was published online April 15 in the journal Advanced Science.

Heart disease is the leading cause of death in the United States. A transplant is the only treatment available to patients with end-stage heart failure, but there is a severe shortage of heart donors.

That means there’s an urgent need to develop new ways to regenerate a diseased heart, according to the researchers.

The use of biological materials from a patient is key to successful engineering of tissues and organs, Dvir explained. The compatibility of engineered materials is key to eliminating rejection risk.

“Ideally, the biomaterial should possess the same biochemical, mechanical and topographical properties of the patient’s own tissues,” Dvir noted. “Here, we can report a simple approach to 3D-printed thick, vascularized and perfusable cardiac tissues that completely match the immunological, cellular, biochemical and anatomical properties of the patient.”

Continued

While the 3D-printed heart is about the size of a rabbit’s heart, the same technology can be used to print a normal-sized one, he said.

The next step is culturing printed hearts in the lab and “teaching them to behave” like hearts, Dvir added. Then, researchers plan to transplant the 3D-printed heart into lab animals.

“We need to develop the printed heart further,” Dvir said. “The cells need to form a pumping ability; they can currently contract, but we need them to work together. Our hope is that we will succeed and prove our method’s efficacy and usefulness.”

Dvir looks to the future with optimism.

“Maybe, in 10 years, there will be organ printers in the finest hospitals around the world, and these procedures will be conducted routinely,” he said.

WebMD News from HealthDay

Sources

SOURCE: Tel Aviv University, news release, April 15, 2019

Copyright © 2013-2018 HealthDay. All rights reserved.

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WebMD Health

Israeli Team Announces First 3D-Printed Heart Using Human Cells

MONDAY, April 15, 2019 — The world’s first complete 3D printer-generated heart, made using the patient’s own cells and materials, has been created in a lab.

Until now, success has been limited to printing only simple tissues without blood vessels.

“This is the first time anyone anywhere has successfully engineered and printed an entire heart replete with cells, blood vessels, ventricles and chambers,” said team leader Tal Dvir.

The printer-generated heart is only about a third the size of an actual human heart — and it doesn’t actually work. But it’s a groundbreaking step toward engineering customized organs that can be transplanted with less risk of rejection.

“This heart is made from human cells and patient-specific biological materials,” said Dvir, a researcher at the Sagol Center for Regenerative Biotechnology at Tel Aviv University in Israel. “In our process these materials serve as the bio-inks, substances made of sugars and proteins that can be used for 3D printing of complex tissue models.”

Dvir noted that scientists have managed to print a 3D structure of a heart before, but not with cells or blood vessels. “Our results demonstrate the potential of our approach for engineering personalized tissue and organ replacement in the future,” he said in a university news release.

The research was published online April 15 in the journal Advanced Science.

Heart disease is the leading cause of death in the United States. A transplant is the only treatment available to patients with end-stage heart failure, but there is a severe shortage of heart donors.

That means there’s an urgent need to develop new ways to regenerate a diseased heart, according to the researchers.

The use of biological materials from a patient is key to successful engineering of tissues and organs, Dvir explained. The compatibility of engineered materials is key to eliminating rejection risk.

“Ideally, the biomaterial should possess the same biochemical, mechanical and topographical properties of the patient’s own tissues,” Dvir noted. “Here, we can report a simple approach to 3D-printed thick, vascularized and perfusable cardiac tissues that completely match the immunological, cellular, biochemical and anatomical properties of the patient.”

While the 3D-printed heart is about the size of a rabbit’s heart, the same technology can be used to print a normal-sized one, he said.

The next step is culturing printed hearts in the lab and “teaching them to behave” like hearts, Dvir added. Then, researchers plan to transplant the 3D-printed heart into lab animals.

“We need to develop the printed heart further,” Dvir said. “The cells need to form a pumping ability; they can currently contract, but we need them to work together. Our hope is that we will succeed and prove our method’s efficacy and usefulness.”

Dvir looks to the future with optimism.

“Maybe, in 10 years, there will be organ printers in the finest hospitals around the world, and these procedures will be conducted routinely,” he said.

More information

The U.S. National Heart, Lung, and Blood Institute has more on heart failure.

© 2019 HealthDay. All rights reserved.

Posted: April 2019

Drugs.com – Daily MedNews

Why Using Pure CBD Tinctures Can Be Good For Pain

People suffering from chronic pain may be desperately searching for an effective medicine to alleviate their condition. If you’re dealing with recurrent pain such as migraines, arthritis, or even pain caused by cancer, you may want to explore using CBD tinctures to manage your symptoms. CBD may be an alternative to taking prescribed medications for a long period of time. Here’s why using CBD tinctures may be good for solving your pain.

What CBD tinctures are

CBD stands for cannabidiol. It is a natural compound that is found in hemp or cannabis plants. Hemp flowers that are rich in cannabidiol are first marinated in potent grain alcohol. Afterwards, the hemp flowers are boiled over low heat for a few hours. The end result is cannabidiol or CBD tincture.

Afterwards, the tincture is mixed with a palatable carrier oil such as peppermint so that it’s easy for consumers or patients to ingest it. Although the CBD tincture has a notably high cannabidiol content, it’s still a totally different preparation from a cannabis tincture.

CBD tinctures have a very low level of tetrahydrocannabinol (THC) and is therefore not psychoactive. You won’t get high from taking a CBD tincture. On the other hand, cannabis tinctures contain all types of cannabinoids including THC. Cannabis tinctures may give you the feeling of euphoria or being high.

How CBD tinctures can help you

As CBD is not psychoactive, taking the Every Day Optimal CBD tinctures won’t alter your state of mind or affect how you think. What it does is boost your body’s endocannabinoid system so that it acts to take care of your body. For instance, when you take drops of a CBD tincture, it can affect your body by inhibiting it from absorbing the compound called anandamide, which manages pain. Because your body doesn’t easily absorb or consume anandamide after taking CBD, the level of anandamide increases in your bloodstream. The boost in anandamide will help you feel pain less.

Cannabidiol may likewise control inflammation that’s found in a person’s brain and nervous system. When inflammation is controlled, it can decrease your feelings of pain as well as other negative symptoms.

One advantage of taking CBD tinctures over traditional medications is that you won’t become dependent on CBD. Once your symptoms improve over time, you may taper off and stop taking the tincture. Your body likewise won’t get used to taking a CBD tincture, so there’s no need to continually increase the dosage you take over a prolonged period of time.

How CBD can address specific types of pain

 

Several researches have been conducted regarding how CBD can alleviate pain. Here are a few examples:

  • Arthritis pain

 

An estimated 50 million adults in the U.S. suffer from arthritis or related rheumatic diseases that trigger joint pain. Many adults have to deal with possibly debilitating joint pain on a regular basis.

Patients who suffer from arthritis experience stiffness and an inability to move their joints well. Over time, these symptoms may worsen and may cause more pain. What may make matters worse is that arthritis may be concomitant with other illnesses such as heart disease and diabetes.

If this is your situation, you may want to discuss trying out CBD tinctures with your physician in order to address your arthritis pain naturally. There are certain pain medications that may interfere with your heart condition or diabetes. CBD tinctures are a natural and effective alternative to typical pain medicines.

In one study, CBD was discovered to address pain and nerve damage found in rats suffering from osteoarthritis, with no noted side effects experienced by the rats. Human studies, however, need to be conducted to see how CBD affects arthritis. You may want to explore how taking CBD tinctures can alleviate your arthritis pain under the guidance of your doctor.

 

  • Chronic pain

 

In another study on the healing effects of cannabinoids, it was discovered that patients who were suffering from chronic pain and were given CBD experienced a clinically notable decrease in their pain symptoms. The same study likewise recorded that cannabidiol may help patients suffering from pain caused by multiple sclerosis muscle spasms.

If you suffer from chronic pain or multiple sclerosis, CBD tinctures may provide you with a safe and natural form of treatment.

Conclusion

 

CBD, like what’s found in tinctures, may do wonders to ease pain. However, more longitudinal studies need to be done with human patients. As of now, what’s known is that CBD tinctures are an effective alternative for addressing varied types of pain. The good news is that CBD tinctures are not addictive and cause fewer or milder side effects than those caused by stronger pain medications.

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Shane Dwyer
Author: Shane Dwyer
Shane Dwyer is a cannabis advocate who isn’t afraid to tell the world about it! You can find his views, rants, and tips published regularly at The 420 Times.

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Indonesia police apologise for using snake in Papua interrogation

JAKARTA (Reuters) – Indonesian police have apologised and pledged disciplinary action after officers draped a live snake around the neck of a suspect to persuade him to confess during an interrogation session in the easternmost area of Papua.

A video circulated online shows a man being questioned about stolen mobile phones seated with his hands tethered behind his back yelling in distress as a snake is pushed towards his face by an officer.

The man, who can been seen writhing on the ground for much of the time is asked by an officer, “How may times have you stolen mobile phones?”

The suspect later responds by saying, “Only two times.”

During the video, a voice can be heard ordering the man to open his eyes and at one stage threatens to put the snake into his mouth and under his trousers.

In a statement, Jayawijaya police chief Tonny Ananda Swadaya issued an apology, saying, “The investigator was not professional in doing his job”.

Swadaya added that the officers had been acting on their own initiative to try get a confession, saying the snake was non-venomous and tame.

“We have taken stern action against the personnel,” he said, adding the officers themselves had not physically attacked the man.

Papua police spokesman Ahmad Musthofa Kamal said the case was being investigated by the internal affairs unit and if violations of the law or code of conduct were proven action would be taken.

Reports of human rights abuses by security forces often emerge from Papua, where a separatist movement has simmered for decades.

The former Dutch colony, the resource-rich western part New Guinea island, was incorporated into Indonesia after a widely criticized U.N.-backed referendum in 1969.

Veronica Koman, a human rights lawyer focused on Papua, said by text message that using a snake in this way represented torture and was not a one-off incident in the area.

Koman said a snake had also been used in an interrogation of one of her clients, whom she said was a pro-independence activist.

Papua police spokesman Kamal said he was not aware of another case.

(This story was refiled to correct 13th paragraph, lawyer says client “pro-independence activist” not a “separatist”)

Reporting by Agustinus Beo Da Costa; Writing by Ed Davies; Editing by Clarence Fernandez

Reuters: Oddly Enough

Too Many Kids Using Too Much Toothpaste, CDC Says

Overuse of toothpaste puts many young American children at increased risk for splotchy or streaky teeth when they’re older, a U.S. Centers for Disease Control and Prevention survey finds.

The poll of more than 5,000 parents of children aged 3 to 15 found that 40 percent of children aged 3 to 6 used a brush that was full or half-full of toothpaste, rather than the recommended pea-sized amount, the Associated Press reported.

Health officials say children under age 3 should use a smear of toothpaste the size of a grain of rice, while those aged 3 to 6 should limit it to a pea-sized amount.

The problem with using too much toothpaste is the fluoride in it. While fluoride protects teeth, too much of it when teeth are forming can lead to tooth streaking or spottiness (dental fluorosis), the AP reported.

The survey also found that about 60 percent of children brushed their teeth twice a day, and that about 20 percent of white and black kids, and 30 percent of Hispanic kids, didn’t start brushing until they were 3 or older, the AP reported.

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Are Some People Using Their Dogs to Get Opioids?

By Dennis Thompson

HealthDay Reporter

TUESDAY, Jan. 15, 2019 (HealthDay News) — To fight America’s opioid epidemic, lawmakers and regulators have clamped down hard on doctors’ prescribing practices.

But one avenue for obtaining prescription opioids appears to have been overlooked, according to a new study.

Veterinarians are prescribing large quantities of opioids to pets, raising concern that some people might be using Fido or Snuggles to feed their addiction.

Opioid prescriptions from the University of Pennsylvania’s School of Veterinary Medicine rose 41 percent between 2007 and 2017, even though the annual number of visits increased by just 13 percent, researchers found.

Penn Vet handed out 105 million tramadol tablets, 97,500 hydrocodone (Hycodan) tablets, and nearly 39,000 codeine tablets during the study period, results show.

“I think it would come as a surprise to everyone, the quantities,” said senior author Dr. Jeanmarie Perrone, director of medical toxicology at the University of Pennsylvania’s Perelman School of Medicine.

Not Just For Pets

It’s very likely at least some of these drugs wound up being used by humans, said Emily Feinstein, executive vice president of the Center on Addiction.

“There’s a small percentage, I’m sure, of people in this data who are using their pets and an encounter with a veterinarian as a means of getting themselves opioids,” Feinstein said.

The U.S. opioid crisis led to roughly 50,000 overdose deaths in 2017, according to the U.S. Centers for Disease Control and Prevention.

Americans now are more likely to die from an opioid overdose than from a car or motorcycle crash, a fall, drowning or choking on food, a report issued Tuesday by the National Safety Council concluded.

Perrone initiated her study after vet school colleagues complained that they’d been getting a lot of after-hours calls from patients about filling opioid prescriptions for pets. They asked her advice about how to handle these requests.

“Before I went to talk, I asked them to pull all of their opioid prescriptions so I’d have an idea how often they actually prescribed opioids,” Perrone said. “To their shock and our shock, there were about 3,000 prescriptions a month.”

Perrone thought back to when she’d had her own dog spayed, and the vet handed her a bag of supplies to care for her recovering canine. She went looking for that bag.

“I found a bottle of tramadol I was given when my dog got spayed four years ago. It was still in the cabinet with all the dog stuff,” Perrone said.

Continued

Following general trends

After looking at Penn Vet’s prescribing practices, Perrone’s team obtained statewide prescription data kept by the U.S. Drug Enforcement Agency for all Pennsylvania veterinarians.

Between 2014 and 2017, Pennsylvania vets doled out 688,340 hydrocodone (Hycodan) tablets, 14,100 codeine tablets, 23,110 fentanyl patches, 171,100 tablets of hydromorphone (Dilaudid) and 7,600 doses of oxycodone (Oxycontin), the federal data showed.

The findings were published Jan. 10 in the journal JAMA Network Open.

The opioid epidemic stems from a shift in medical philosophy, in which pain‘s role as a symptom to be treated became more prominent and the risks of opioid addiction were not fully appreciated, Feinstein said.

“Veterinarians live in the same society as the rest of us,” she said. “It’s not surprising to see the same trends happening in veterinary medicine as were happening in the rest of medicine. All of medicine was prescribing more opioids and thinking they were safe.”

Beyond the risk of people “vet shopping” for drugs, Feinstein said the numbers suggest pet cabinets across the country might contain opioids ripe for misuse.

“If there is someone with an opioid use problem in your circle, those leftover pills can become a temptation if they’re not safely locked up,” she said.

Dr. John de Jong, president of the American Veterinary Medical Association, said he hasn’t seen any data to suggest that what was found in Pennsylvania is occurring elsewhere.

“First, this is a survey of veterinarians at a veterinary teaching hospital to which complex cases are referred and for which more extensive pain management is often needed,” de Jong said. “It is inappropriate to extrapolate results from a practice like that to primary care practices across the country.”

Second, pain management is a rapidly emerging field in veterinary medicine, de Jong said.

“The period of this study overlaps a period of significant growth in understanding pain and its impact on veterinary patients,” he said. “It is reasonable to expect that as knowledge grows, so will efforts to address related concerns. So, it’s very possible that this study doesn’t reflect overprescribing, but instead reflects appropriate prescribing representing better pain management in veterinary patients.”

Continued

Better Monitoring

At the same time, vets are starting to keep a closer eye on their opioid prescriptions, de Jong added.

“There appear to have been few confirmed cases of owners deliberately injuring their pets to obtain opioids,” he said. “We have heard more veterinarians share that they suspect some pet owners may be using their pet’s medications and asking for refills in advance of when those should be needed, or that they’ve lost or spilled medications, but this is anecdotal.”

These results suggest vets need to be urged as strongly as other doctors to prescribe opioids with care, said Dr. Harshal Kirane, director of addiction services at Staten Island University Hospital in New York.

“Our national response to the opioid epidemic should leave no stone unturned,” Kirane said. “This work highlights that contemporary veterinary medicine uses a significant volume of opioid medications, yet lacks a systematic framework for safe opioid-prescribing practices. While the apparent scale of opioid medication management in animals is drastically smaller in comparison to humans, it still represents a powerful opportunity for practice improvement.”

In the meantime, pet owners should secure any opioids prescribed for their animals, and dispose of the drugs safely when they’re no longer needed, said Dr. Scott Krakower, assistant unit chief of psychiatry at Zucker Hillside Hospital in Glen Oaks, N.Y.

“I feel like sometimes you don’t even think of it. It may slip your mind that the medication is there in the cabinet,” Krakower said. “Sometimes it’s not clearly marked as a human medication may be.”

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Pagination

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